Publications

Terry AQ, Kojima H, Sosa RA, Kaldas FM, Chin JL, Zheng Y, Naini BV, Noguchi D, Nevarez-Mejia J, Jin YP, Busuttil RW, Meyer AS, Gjertson DW, Kupiec-Weglinski JW, Reed EF. Disulfide-HMGB1 signals through TLR4 and TLR9 to induce inflammatory macrophages capable of innate-adaptive crosstalk in human liver transplantation. Am J Transplant. 2023 Dec;23(12):1858-1871. doi: 10.1016/j.ajt.2023.08.002. Epub 2023 Aug 9. PMID: 37567451; PMCID: PMC11095628.

Sosa RA, Terry AQ, Ito T, Naini BV, Zheng Y, Pickering H, Nevarez-Mejia J, Busuttil RW, Gjertson DW, Kupiec-Weglinski JW, Reed EF, Kaldas FM. Immune Features of Disparate Liver Transplant Outcomes in Female Hispanics With Nonalcoholic Steatohepatitis. Transplant Direct. 2023 Oct 20;9(11):e1550. doi: 10.1097/TXD.0000000000001550. PMID: 37876917; PMCID: PMC10593264.

Rosenberg-Hasson Y, Holmes TH, Diray-Arce J, Chen J, Kellogg R, Snyder M, Becker PM, Ozonoff A, Rouphael N, Reed EF; IMPACC Network; Maecker HT. Relationship of Heterologous Virus Responses and Outcomes in Hospitalized COVID-19 Patients. J Immunol. 2023 Oct 15;211(8):1224-1231. doi: 10.4049/jimmunol.2300391. PMID: 37756530; PMCID: PMC10539027.

Locke AF, Hickey M, Valenzuela NM, Butler C, Sosa R, Zheng Y, Gjertson D, Reed EF, Zhang Q. Virtual Crossmatch: By Any Other Name. Transplantation. 2023 Oct 1;107(10):e274. doi: 10.1097/TP.0000000000004724. Epub 2023 Sep 25. PMID: 37749817.

Locke AF, Hickey M, Valenzuela NM, Butler C, Sosa R, Zheng Y, Gjertson D, Reed EF, Zhang Q. Virtual and Reality: An Analysis of the UCLA Virtual Crossmatch Exchanges. Transplantation. 2023 Aug 1;107(8):1776-1785. doi: 10.1097/TP.0000000000004586. Epub 2023 Jul 20. PMID: 36944607; PMCID: PMC10358445.

Lichtenstein B, Zheng Y, Gjertson D, Ferbas KG, Rimoin AW, Yang OO, Aldrovandi GM, Schaenman JM, Reed EF, Fulcher JA. Vascular and Non-HLA autoantibody profiles in hospitalized patients with COVID-19. Front Immunol. 2023 Jun 15;14:1197326. doi: 10.3389/fimmu.2023.1197326. PMID: 37398658; PMCID: PMC10309004.

Sigdel TK, Boada P, Kerwin M, Rashmi P, Gjertson D, Rossetti M, Sur S, Munar D, Cimino J, Ahn R, Pickering H, Sen S, Parmar R, Fatou B, Steen H, Schaenman J, Bunnapradist S, Reed EF, Sarwal MM; CMV Systems Immunobiology Group. Plasma proteome perturbation for CMV DNAemia in kidney transplantation. PLoS One. 2023 May 19;18(5):e0285870. doi: 10.1371/journal.pone.0285870. PMID: 37205661; PMCID: PMC10198483.

Jenkins MM, Phan Tran D, Flores EA, Kupferwasser D, Pickering H, Zheng Y, Gjertson DW, Ross TM, Schaenman JM, Miller LG, Yeaman MR, Reed EF. Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants. Front Immunol. 2023 Apr 19;14:1139915. doi: 10.3389/fimmu.2023.1139915. PMID: 37153624; PMCID: PMC10154521.

Anwar T, Sinnett-Smith J, Jin YP, Reed EF, Rozengurt E. Lipophilic Statins Inhibit YAP Nuclear Localization, Coactivator Activity, and Migration in Response to Ligation of HLA Class I Molecules in Endothelial Cells: Role of YAP Multisite Phosphorylation. J Immunol. 2023 Apr 15;210(8):1134-1145. doi: 10.4049/jimmunol.2200568. PMID: 36881871; PMCID: PMC10073314.

Sosa RA, Mone T, Naini BV, Kohn DB, Reed EF, Wheeler K, Campo-Fernandez B, Davila A, Chaffin DJ, DiNorcia J, Kaldas FM, Cohen A, Lum EL, Veale JL, Kogut NM. Apheresis of Deceased Donors as a New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance. Transplantation. 2023 Feb 1;107(2):504-510. doi: 10.1097/TP.0000000000004288. Epub 2022 Aug 17. PMID: 35974436; PMCID: PMC9877104.

Tambur AR, Bestard O, Campbell P, Chong AS, Barrio MC, Ford ML, Gebel HM, Heidt S, Hickey M, Jackson A, Kosmoliaptsis V, Lefaucheur C, Louis K, Mannon RB, Mengel M, Morris A, Pinelli DF, Reed EF, Schinstock C, Taupin JL, Valenzuela N, Wiebe C, Nickerson P. Sensitization in transplantation: Assessment of Risk 2022 Working Group Meeting Report. Am J Transplant. 2023 Jan;23(1):133-149. doi: 10.1016/j.ajt.2022.11.009. Epub 2023 Jan 11. Erratum in: Am J Transplant. 2023 May;23(5):694. doi: 10.1016/j.ajt.2023.03.002. PMID: 36695615.

Lefaucheur C, Louis K, Morris AB, Taupin JL, Nickerson P, Tambur AR, Gebel HM, Reed EF; STAR 2022 Working Group. Clinical recommendations for posttransplant assessment of anti-HLA (Human Leukocyte Antigen) donor-specific antibodies: A Sensitization in Transplantation: Assessment of Risk consensus document. Am J Transplant. 2023 Jan;23(1):115-132. doi: 10.1016/j.ajt.2022.11.013. Epub 2023 Jan 11. PMID: 36695614.

• Shaw BI, Lee HJ, Ettenger R, Grimm P, Reed EF, Sarwal M, Stempora L, Warshaw B, Zhao C, Martinez OM, MacIver NJ, Kirk AD, Chambers ET. Malnutrition and immune cell subsets in children undergoing kidney transplantation. Pediatr Transplant. 2022 Aug 8. doi: 10.1111/petr.14371. Epub ahead of print. PMID: 35938682.
• Sosa RA, Mone T, Naini BV, Kohn DB, Reed EF, Wheeler K, Campo-Fernandez B, Davila A, Chaffin DJ, DiNorcia J, Kaldas FM, Cohen A, Lum EL, Veale JL, Kogut NM. Apheresis of Deceased Donors as a New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance. Transplantation. 2022 Aug 17. doi: 10.1097/TP.0000000000004288. Epub ahead of print. PMID: 35974436.
• Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N; IMPACC study group members. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. EBioMedicine. 2022 Aug 8;83:104208. doi: 10.1016/j.ebiom.2022.104208. Epub ahead of print. PMID: 35952496; PMCID: PMC9359694.
• Pearl M, Weng PL, Chen L, Dokras A, Pizzo H, Garrison J, Butler C, Zhang J, Reed EF, Kim IK, Choi J, Haas M, Zhang X, Vo A, Chambers ET, Ettenger R, Jordan S, Puliyanda D. Long term tolerability and clinical outcomes associated with tocilizumab in the treatment of refractory antibody mediated rejection (AMR) in pediatric renal transplant recipients. Clin Transplant. 2022 Jun 3:e14734. doi: 10.1111/ctr.14734. Epub ahead of print. PMID: 35657013.
• Kamath M, Shekhtman G, Grogan T, Hickey MJ, Silacheva I, Shah KS, Shah KS, Hairapetian A, Gonzalez D, Godoy G, Reed EF, Elashoff D, Bondar G, Deng MC. Variability in Donor-Derived Cell-Free DNA Scores to Predict Mortality in Heart Transplant Recipients - A Proof-of-Concept Study. Front Immunol. 2022 Feb 18;13:825108. doi: 10.3389/fimmu.2022.825108. PMID: 35251005; PMCID: PMC8895247.
• Pickering H, Schaenman J, Rossetti M, Ahn R, Sunga G, Liang EC, Bunnapradist S, Reed EF. T cell senescence and impaired CMV-specific response are associated with infection risk in kidney transplant recipients. Hum Immunol. 2022 Apr;83(4):273-280. doi: 10.1016/j.humimm.2022.01.016. Epub 2022 Feb 18. PMID: 35190203.
• Wozniak LJ, Venick RS, Naini BV, Scapa J, Hickey MJ, Rossetti M, Korin Y, Reed EF, Farmer DG, Busuttil RW, Vargas JH, McDiarmid SV. Operational tolerance is not always permanent: A 10-year prospective study in pediatric liver transplantation recipients. Liver Transpl. 2022 Apr 8. doi: 10.1002/lt.26474. Epub ahead of print. PMID: 35395132.
• Tsuda H, Dvorina N, Keslar KS, Nevarez-Mejia J, Valenzuela NM, Reed EF, Fairchild RL, Baldwin WM 3rd. Molecular Signature of Antibody-Mediated Chronic Vasculopathy in Heart Allografts in a Novel Mouse Model. Am J Pathol. 2022 Jul;192(7):1053-1065. doi: 10.1016/j.ajpath.2022.04.003. Epub 2022 Apr 29. PMID: 35490714; PMCID: PMC9253905.
• Reed EF, Chong AS, Levings MK, Mutrie C, Laufer TM, Roncarolo MG, Sykes M. The Women of FOCIS: Promoting Equality and Inclusiveness in a Professional Federation of Clinical Immunology Societies. Front Immunol. 2022 Apr 4;13:816535. doi: 10.3389/fimmu.2022.816535. PMID: 35444663; PMCID: PMC9015160.
• Ishiyama K, Arakawa-Hoyt J, Aguilar OA, Damm I, Towfighi P, Sigdel T, Tamaki S, Babdor J, Spitzer MH, Reed EF, Sarwal MM, Lanier LL; CMV Systems Immunobiology Group. Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2116588119. doi: 10.1073/pnas.2116588119. PMID: 35181606; PMCID: PMC8872722.
• Ahn R, Schaenman J, Qian Z, Pickering H, Groysberg V, Rossetti M, Llamas M, Hoffmann A, Gjertson D, Deng M, Bunnapradist S, Reed EF; CMV Systems Immunobiology Group. Acute and Chronic Changes in Gene Expression After CMV DNAemia in Kidney Transplant Recipients. Front Immunol. 2021 Nov 15;12:750659. doi: 10.3389/fimmu.2021.750659. PMID: 34867983;PMCID: PMC8634678.
• Simon V, Kota V, Bloomquist RF, Hanley HB, Forgacs D, Pahwa S, Pallikkuth S, Miller LG, Schaenman J, Yeaman MR, Manthei D, Wolf J, Gaur AH, Estepp JH, Srivastava K, Carreño JM, Cuevas F; PARIS/SPARTA Study Group,, Ellebedy AH, Gordon A, Valdez R, Cobey S, Reed EF , Kolhe R, Thomas PG, Schultz-Cherry S, Ross TM, Krammer F. PARIS and SPARTA: Finding the Achilles' Heel of SARS-CoV-2. mSphere. 2022 Jun 29;7(3):e0017922. doi: 10.1128/msphere.00179-22. Epub 2022 May 19. PMID: PMID: 35586986; PMCID: PMC9241545.
• Jin YP, Nevarez-Mejia J, Terry AQ, Sosa RA, Heidt S, Valenzuela NM, Rozengurt E, Reed EF. Cross-Talk between HLA Class I and TLR4 Mediates P-Selectin Surface Expression and Monocyte Capture to Human Endothelial Cells. J Immunol. 2022 Oct 1;209(7):1359-1369. doi: 10.4049/jimmunol.2200284. Epub 2022 Sep 2. PMID: 36165200; PMCID: PMC9635437.

• Pickering H, Sen S, Arakawa-Hoyt J, Ishiyama K, Sun Y, Parmar R, Ahn R, Sunga G, Llamas M, Hoffmann A, Deng M, Bunnapradist S, Schaenman JM, Gjertson DW, Rossetti M, Lanier LL, Reed EF. NK and CD8 T cell phenotypes predict onset and control of CMV viremia post-kidney transplant. JCI Insight. 2021 Oct 5:e153175. doi: 10.1172/jci.insight.153175. Epub ahead of print. PMID: 34609965.
• Schaenman JM, Rossetti M, Liang EC, Lum E, Abdalla B, Bunnapradist S, Pham PT, Danovitch G, Reed EF, Cole SW. Leukocyte transcriptome indicators of development of infection in kidney transplant recipients. Clin Transplant. 2021 Feb 11:e14252. doi: 10.1111/ctr.14252. Epub ahead of print. PMID: 33570750.
• Chan AP, Guerra MR, Rossetti M, Hickey MJ, Venick RS, Marcus EA, McDiarmid SV, Farmer DG, Reed EF, Wozniak LJ. Non-HLA AT1R antibodies are highly prevalent after pediatric intestinal transplantation. Pediatr Transplant. 2021 Feb 16:e13987. doi: 10.1111/petr.13987. Epub ahead of print. PMID: 33590644.
• Chang YL, Rossetti M, Gjertson DW, Rubbi L, Thompson M, Montoya DJ, Morselli M, Ruffin F, Hoffmann A, Pellegrini M, Fowler VG Jr, Yeaman MR, Reed EF; with the MRSA Systems Immunology Group. Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2000663118. doi: 10.1073/pnas.2000663118. PMID: 33649198; PMCID: PMC7958259.
• Crespo M, Llinàs-Mallol L, Redondo-Pachón D, Butler C, Gimeno J, Pérez-Sáez MJ, Burballa C, Buxeda A, Arias-Cabrales C, Folgueiras M, Sanz-Ureña S, Valenzuela NM, Reed EF, Pascual J. Non-HLA Antibodies and Epitope Mismatches in Kidney Transplant Recipients With Histological Antibody-Mediated Rejection. Front Immunol. 2021 Jul 6;12:703457. doi: 10.3389/fimmu.2021.703457. PMID: 34305943; PMCID: PMC8300190.
• Cone BD, Zhang JQ, Sosa RA, Calabrese F, Reed EF, Fishbein GA. Phosphorylated S6 ribosomal protein expression by immunohistochemistry correlates with de novo donor-specific HLA antibodies in lung allograft recipients. J Heart Lung Transplant. 2021 Jul 10:S1053-2498(21)02401-3. doi: 10.1016/j.healun.2021.06.021. Epub ahead of print. PMID: 34330604.
• Whang EC, Rossetti M, Guerra MR, Cheng E, Marcus EA, McDiarmid SV, Venick RS, Farmer DG, Reed EF, Wozniak LJ. Differential cytokine and chemokine expression during rejection and infection following intestinal transplantation. Transpl Immunol. 2021 Aug 13;69:101447. doi: 10.1016/j.trim.2021.101447. Epub ahead of print. PMID: 34400246.
• Shino MY, Zhang Q, Li N, Derhovanessian A, Ramsey A, Saggar R, Britton IN, Amubieya OO, Lari SM, Hickey M, Reed EF, Noble PW, Stripp BR, Fishbein GA, Lynch Rd JP, Ardehali A, Sayah DM, Weigt SS, Belperio JA. The allograft injury marker CXCL9 determines prognosis of anti-HLA antibodies after lung transplantation. Am J Transplant. 2021 Aug 31. doi: 10.1111/ajt.16827. Epub ahead of print. PMID: 34464505.
• IMPACC Manuscript Writing Team; IMPACC Network Steering Committee. Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study. Sci Immunol. 2021 Aug 10;6(62):eabf3733. doi: 10.1126/sciimmunol.abf3733. PMID: 34376480.

• Schaenman J, Phonphok K, Spanuchart I, Duong T, Sievers TM, Lum E, Reed EF, Bunnapradist S. Early cytomegalovirus DNAemia and antiviral dose adjustment in high vs intermediate risk kidney transplant recipients. Transplant Infectious Disease. 2021 Feb;23(1):e13457. doi: 10.1111/tid.13457. Epub 2020 Sep 20. PMID: 32892447
• Shaw BI, Lee HJ, Chan C, Ettenger R, Grimm P, Pearl M, Reed EF, Robien MA, Sarwal M, Stempora L, Warshaw B, Zhao C, Martinez OM, Kirk AD, Chambers ET. Relationship between antithymocyte globulin, T cell phenotypes, and clinical outcomes in pediatric kidney transplantation. American Journal of Transplantation. 2021 Feb;21(2):766-775.doi: 10.1111/ajt.16263. Epub 2020 Sep 1. PMID: 33480466
• Khachatoorian Y, Khachadourian V, Chang E, Sernas ER, Reed EF, Deng M, Piening BD, Pereira AC, Keating B, Cadeiras M. Noninvasive biomarkers for prediction and diagnosis of heart transplantation rejection. Transplant Reviews. 2021 Jan;35(1):100590.doi: 10.1016/j.trre.2020.100590. Epub 2020 Nov 21. PMID: 33401139
• Wozniak LJ, Hickey MJ, Chan AP, Venick RS, Farmer DG, Busuttil RW, Reed EF, McDiarmid SV. Angiotensin II Type-1 Receptor Antibodies Are Associated With Active Allograft Dysfunction Following Pediatric Liver Transplantation. Transplantation. 2020 Dec;104(12):2547-2556.doi: 10.1097/TP.0000000000003206. PMID: 32101982
• Wei X, Valenzuela NM, Rossetti M, Sosa RA, Nevarez-Mejia J, Fishbein GA, Mulder A, Dhar J, Keslar KS, Baldwin WM 3rd, Fairchild RL, Hou J, Reed EF. Antibody-induced vascular inflammation skews infiltrating macrophages to a novel remodeling phenotype in a model of transplant rejection. American Journal of Transplantation. 2020 Oct;20(10):2686-2702.doi: 10.1111/ajt.15934. Epub 2020 May 22. PMID: 32320528
• Tambur AR, Campbell P, Chong AS, Feng S, Ford ML, Gebel H, Gill RG, Kelsoe G, Kosmoliaptsis V, Mannon RB, Mengel M, Reed EF, Valenzuela NM, Wiebe C, Dijke IE, Sullivan HC, Nickerson P. Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report. American Journal of Transplantation. 2020 Oct;20(10):2652-2668.doi: 10.1111/ajt.15937. Epub 2020 May 27. PMID: 32342639
• Butler CL, Hickey MJ, Jiang N, Zheng Y, Gjertson D, Zhang Q, Rao P, Fishbein GA, Cadeiras M, Deng MC, Banchs HL, Torre G, DeNofrio D, Eisen HJ, Kobashigawa J, Starling RC, Kfoury A, Van Bakel A, Ewald G, Balazs I, Baas AS, Cruz D, Ardehali R, Biniwale R, Kwon M, Ardehali A, Nsair A, Ray B, Reed EF. Discovery of non-HLA antibodies associated with cardiac allograft rejection and development and validation of a non-HLA antigen multiplex panel: From bench to bedside. . American Journal of Transplantation. 2020 Oct;20(10):2768-2780.doi: 10.1111/ajt.15863. Epub 2020 Apr 26. PMID: 32185871
• Kageyama S, Kadono K, Hirao H, Nakamura K, Ito T, Gjertson DW, Sosa RA, Reed EF, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. Ischemia-Reperfusion Injury in Allogeneic Liver Transplantation: A Role of CD4 T Cells in Early Allograft Injury. Transplantation. 2020 Oct 15.doi: 10.1097/TP.0000000000003488. Epub ahead of print. PMID: 33065722
• Anwar T, Sinnett-Smith J, Jin YP, Reed EF, Rozengurt E. Ligation of HLA Class I Molecules Induces YAP Activation through Src in Human Endothelial Cells. Journal of Immunology. 2020 Oct 1;205(7):1953-1961.doi: 10.4049/jimmunol.2000535. Epub 2020 Aug 26. PMID: 32848033
• Pearl MH, Chen L, ElChaki R, Elashoff D, Gjertson DW, Rossetti M, Weng PL, Zhang Q, Reed EF, Chambers ET. Endothelin Type A Receptor Antibodies Are Associated With Angiotensin II Type 1 Receptor Antibodies, Vascular Inflammation, and Decline in Renal Function in Pediatric Kidney Transplantation. Kidney International Reports. 2020 Sep 6;5(11):1925-1936.doi: 10.1016/j.ekir.2020.09.004. PMID: 33163713
• Burballa C, Pérez-Saéz MJ, Redondo-Pachón D, García C, Mir M, Arias-Cabrales C, Valenzuela NM, Reed EF, Pascual J, Crespo M. Luminex screening first vs. direct single antigen bead assays: Different strategies for HLA antibody monitoring after kidney transplantation. Human Immunology. 2020 Jun;81(6):293-299.doi: 10.1016/j.humimm.2020.03.003. Epub 2020 Apr 9. PMID: 32279925
• Sosa RA, Rossetti M, Naini BV, Groysberg VM, Kaldas FM, Busuttil RW, Chang YL, Gjertson DW, Kupiec-Weglinski JW, Reed EF. Pattern Recognition Receptor-reactivity Screening of Liver Transplant Patients: Potential for Personalized and Precise Organ Matching to Reduce Risks of Ischemia-reperfusion Injury. Annals of Surgery. 2020 May;271(5):922-931.doi: 10.1097/SLA.0000000000003085. PMID: 30480558
• Nakamura K, Kageyama S, Kaldas FM, Hirao H, Ito T, Kadono K, Dery KJ, Kojima H, Gjertson DW, Sosa RA, Kujawski M, Busuttil RW, Reed EF, Kupiec-Weglinski JW. Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury. Journal of Clinical Investigation. 2020 May 1;130(5):2689-2704.doi: 10.1172/JCI133142. PMID: 32027621
• Schutt R, Case J, Kurian SM, Spierling Bagsic SR, Barrick BL, Toll AE, Zhang Q, Reed EF, Quigley MM, Schaffer R, Fisher JS, Rice JC, Marsh CL. Safety and Efficacy of a Steroid Avoidance Immunosuppression Regimen in Renal Transplant Patients With De Novo or Preformed Donor-Specific Antibodies: A Single-Center Study. Transplant Proceedings. 2021 Apr;53(3):950-961.doi: 10.1016/j.transproceed.2020.10.021. Epub 2020 Dec 5. PMID: 33293041
• Sosa RA, Terry AQ, Kaldas FM, Jin YP, Rossetti M, Ito T, Li F, Ahn RS, Naini BV, Groysberg VM, Zheng Y, Aziz A, Nevarez-Mejia J, Zarrinpar A, Busuttil RW, Gjertson DW, Kupiec-Weglinski JW, Reed EF. Disulfide High-Mobility Group Box 1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation. Hepatology. 2021 Mar;73(3):1158-1175.doi: 10.1002/hep.31324. Epub 2020 Oct 30. PMID: 32426849
• Geer LI, Kagele S, Townshend S, Watson B, Reed EF, Hickey MJ. Design of a state of the art reporting system and process improvement for reporting of high complexity single antigen bead data for transplant patients to the electronic medical record. BMJ Open Quality. 2020 Jan;9(1):e000813.doi: 10.1136/bmjoq-2019-000813. PMID: 31986117

• Redfield RR, Jordan SC, Busque S, Vincenti F, Woodle ES, Desai N, Reed EF, Tremblay S, Zachary AA, Vo AA, Formica R, Schindler T, Tran H, Looney C, Jamois C, Green C, Morimoto A, Rajwanshi R, Schroeder A, Cascino MD, Brunetta P, Borie D. Safety, pharmacokinetics, and pharmacodynamic activity of obinutuzumab, a type 2 anti-CD20 monoclonal antibody for the desensitization of candidates for renal transplant. American Journal of Transplantation. 2019 Nov;19(11):3035-3045. doi: 10.1111/ajt.15514. Epub 2019 Jul 23. PMID: 31257724
• Mba Medie F, Sharma-Kuinkel BK, Ruffin F, Chan LC, Rossetti M, Chang YL, Park LP, Bayer AS, Filler SG, Ahn R, Reed EF, Gjertson D, Yeaman MR, Fowler VG Jr; MRSA Systems Immunobiology Group. Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients. Proceedings of the National Academy of Sciences of the United States of America. 2019 Oct 1;116(40):20087-20096. doi: 10.1073/pnas.1909849116. Epub 2019 Sep 16. PMID: 31527248
• Pearl MH, Reed EF. Angiotensin II type I receptor antibodies in pediatric solid organ transplant. Human Immunology. 2019 Aug;80(8):568-572. doi: 10.1016/j.humimm.2019.03.016. Epub 2019 Mar 26. PMID: 30926351
• Yin Y, Reed EF, Zhang Q. Integrate CRISPR/Cas9 for protein expression of HLA-B*38:68Q via precise gene editing. Scientific Reports. 2019 May 30;9(1):8067. doi: 10.1038/s41598-019-44336-7. PMID: 31147565
• Schaenman JM, Rossetti M, Lum E, Abdalla B, Bunnapradist S, Pham TP, Danovitch G, Reed EF, Cole S. Differences in Gene Expression in Older Compared With Younger Kidney Transplant Recipients. Transplantation Direct. 2019 Mar 4;5(4):e436. doi: 10.1097/TXD.0000000000000870. PMID: 30993190
• Schaenman JM, Rossetti M, Sidwell T, Groysberg V, Sunga G, Liang E, Vangala S, Chang E, Bakir M, Bondar G, Cadeiras M, Kwon M, Reed EF, Deng M. Association of pro-inflammatory cytokines and monocyte subtypes in older and younger patients on clinical outcomes after mechanical circulatory support device implantation. Human Immunology. 2019 Feb;80(2):126-134. doi: 10.1016/j.humimm.2018.11.004. Epub 2018 Nov 14. PMID: 30445099
• Kageyama S, Hirao H, Nakamura K, Ke B, Zhang M, Ito T, Aziz A, Oncel D, Kaldas FM, Busuttil RW, Sosa RA, Reed EF, Araujo JA, Kupiec-Weglinski JW. Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside. American Journal of Transplantation. 2019 Feb;19(2):356-367. doi: 10.1111/ajt.15043. Epub 2018 Aug 24. PMID: 30059195

• Lan JH, Gjertson D, Zheng Y, Clark S; DeKAF Investigators, Reed EF, Cecka MJ. Clinical utility of complement-dependent C3d assay in kidney recipients presenting with late allograft dysfunction. American Journal of Transplantation. 2018 Dec;18(12):2934-2944. PMID: 29659162
• Sosa RA, Rossetti M, Naini BV, Groysberg VM, Kaldas FM, Busuttil RW, Chang YL, Gjertson DW, Kupiec-Weglinski JW, Reed EF. Pattern Recognition Receptor-reactivity Screening of Liver Transplant Patients: Potential for Personalized and Precise Organ Matching to Reduce Risks of Ischemia-reperfusion Injury. Annals of Surgery. 2018 Nov 22. PMID: 30480558
• Chan LC, Rossetti M, Miller LS, Filler SG, Johnson CW, Lee HK, Wang H, Gjertson D, Fowler VG Jr, Reed EF, Yeaman MR; MRSA Systems Immunobiology Group. Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory. Proceedings of the National Academy of Sciences of the United States of America. 2018 Nov 20;115(47):E11111-E11119. PMID: 30297395
• Schaenman JM, Rossetti M, Sidwell T, Groysberg V, Sunga G, Liang E, Vangala S, Chang E, Bakir M, Bondar G, Cadeiras M, Kwon M, Reed EF, Deng M. Association of pro-inflammatory cytokines and monocyte subtypes in older and younger patients on clinical outcomes after mechanical circulatory support device implantation. Human Immunology. 2018 Nov 14. pii: S0198-8859(18)31022-X. PMID: 30445099
• Zhang Q, Hickey M, Drogalis-Kim D, Zheng Y, Gjertson D, Cadeiras M, Khuu T, Baas AS, Depasquale EC, Halnon NJ, Perens G, Alejos J, Cruz D, Ali N, Shemin R, Kwon M, Fishbein MC, Ardehali A, Deng M, Reed EF. Understanding the Correlation Between DSA, Complement Activation, and Antibody-Mediated Rejection in Heart Transplant Recipients. Transplantation. 2018 Oct;102(10):e431-e438. PMID: 29916988
• Schaenman JM, Rossetti M, Sidwell T, Groysberg V, Sunga G, Korin Y, Liang E, Zhou X, Abdalla B, Lum E, Bunnapradist S, Pham T, Danovitch G, Reed EF. Increased T cell immunosenescence and accelerated maturation phenotypes in older kidney transplant recipients. Human Immunology. 2018 Sep;79(9):659-667. PMID: 29913200
• Bakir M, Jackson NJ, Han SX, Bui A, Chang E, Liem DA, Ardehali A, Ardehali R, Baas AS, Press MC, Cruz D, Deng MC, DePasquale EC, Fonarow GC, Khuu T, Kwon MH, Kubak BM, Nsair A, Phung JL, Reed EF, Schaenman JM, Shemin RJ, Zhang QJ, Tseng CH, Cadeiras M. Clinical phenomapping and outcomes after heart transplantation. Journal of Heart and Lung Transplantation. 2018 Aug;37(8):956-966. PMID: 29802085
• Kageyama S, Hirao H, Nakamura K, Ke B, Zhang M, Ito T, Aziz A, Oncel D, Kaldas FM, Busuttil RW, Sosa RA, Reed EF, Araujo JA, Kupiec-Weglinski JW. Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside. American Journal of Transplantation. 2018 Jul 30. PMID: 30059195
• Roux A, Thomas KA, Sage E, Suberbielle-Boissel C, Beaumont-Azuar L, Parquin F, Le Guen M, Harre N, Hamid AM, Reed EF. Donor-specific HLA antibody-mediated complement activation is a significant indicator of antibody-mediated rejection and poor long-term graft outcome during lung transplantation: a single center cohort study. Transplant International. 2018 Jul;31(7):761-772. PMID: 29537702
• Kageyama S, Nakamura K, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: From bench-to-bedside. Hepatology. 2018 Jul;68(1):258-273. PMID: 29350771
• Salehi S, Sosa RA, Jin YP, Kageyama S, Fishbein MC, Rozengurt E,Kupiec-Weglinski JW, Reed EF. Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial cell-monocyte interactions via mTOR in transplant antibody-mediated rejection. American Journal of Transplantation. 2018 May;18(5):1096-1109. PMID: 29045076
• Nakamura K, Kageyama S, Yue S, Huang J, Fujii T, Ke B, Reed EF, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation: From mouse to human. American Journal of Transplantation. 2018 May;18(5):1110-1121. PMID: 29136322
• Jin YP, Valenzuela NM, Zhang X, Rozengurt E, Reed EF. HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection. Journal of Immunology. 2018 Apr 1;200(7):2372-2390. PMID: 29475988
• Schaenman JM, Rossetti M, Korin Y, Sidwell T, Groysberg V, Liang E, Vangala S, Wisniewski N, Chang E, Bakir M, Bondar G, Cadeiras M, Kwon M, Reed EF, Deng M. T cell dysfunction and patient age are associated with poor outcomes after mechanical circulatory support device implantation. Human Immunology. 2018 Apr;79(4):203-212. PMID: 29409843
• Liang EC, Rossetti M, Sidwell T, Groysberg V, Sunga G, Korin Y, Vangala S, Abdalla B, Lum E, Bunnapradist S, Pham PT, Danovitch G, Reed EF, Schaenman J. Differences in Proinflammatory Cytokines and Monocyte Subtypes in Older as Compared With Younger Kidney Transplant Recipients. Transplantation Direct. 2018 Feb 14;4(3):e348. PMID: 29707619
• Pearl MH, Zhang Q, Palma Diaz MF, Grotts J, Rossetti M, Elashoff D, Gjertson DW, Weng P, Reed EF, Tsai Chambers E. Angiotensin II Type 1 receptor antibodies are associated with inflammatory cytokines and poor clinical outcomes in pediatric kidney transplantation. Kidney International. 2018 Jan;93(1):260-269. PMID: 28927645

• Nakamura K, Zhang M, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury. Journal of Hepatology. 2017 Dec;67(6):1232-1242. PMID: 28842295
• Roedder S, Sigdel T, Hsieh SC, Cheeseman J, Metes D, Macedo C, Reed EF, Gritsch HA, Zeevi A, Shapiro R, Kirk AD, Sarwal MM. Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection. Frontiers in Medicine. 2017 Nov 1;4:185. PMID: 29164120
• Weng PL, Alejos JC, Halnon N, Zhang Q, Reed EF, Tsai Chambers E. Long-term outcomes of simultaneous heart and kidney transplantation in pediatric recipients. Pediatric Transplantation. 2017 Nov;21(7). PMID: 28727227
• Nakamura K, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/Reperfusion: From mouse to human. Liver Transplantation. 2017 Oct;23(10):1282-1293. PMID: 28719070
• Valenzuela NM, Thomas KA, Mulder A, Parry GC, Panicker S, Reed EF. Complement-Mediated Enhancement of Monocyte Adhesion to Endothelial Cells by HLA Antibodies, and Blockade by a Specific Inhibitor of the Classical Complement Cascade, TNT003. Transplantation. 2017 Jul;101(7):1559-1572. PMID: 28640789
• Valenzuela NM, Reed EF. Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapies. Journal of Clinical Investigation. 2017 Jun 30;127(7):2492-2504. PMID: 28604384
• Ettenger R, Chin H, Kesler K, Bridges N, Grimm P, Reed EF, Sarwal M, Sibley R, Tsai E, Warshaw B, Kirk AD. Relationship Among Viremia/Viral Infection, Alloimmunity, and Nutritional Parameters in the First Year After Pediatric Kidney Transplantation. American Journal of Transplantation. 2017 Jun;17(6):1549-1562. PMID: 27989013
• Schaenman JM, Korin Y, Sidwell T, Kandarian F, Harre N, Gjertson D, Lum EL, Reddy U, Huang E, Pham PT, Bunnapradist S, Danovitch GM, Veale J, Gritsch HA, Reed EF. Increased Frequency of BK Virus-Specific Polyfunctional CD8+ T Cells Predict Successful Control of BK Viremia After Kidney Transplantation. Transplantation. 2017 Jun;101(6):1479-1487. PMID: 27391197
• Wozniak LJ, Naini BV, Hickey MJ, Bhattacharyya S, Reed EF, Busuttil RW, Farmer DG, Vargas JH, Venick RS, McDiarmid SV. Acute antibody-mediated rejection in ABO-compatible pediatric liver transplant recipients: case series and review of the literature. Pediatric Transplantation. 2017 Feb;21(1). PMID: 27597379
• Hickey MJ, Zheng Y, Valenzuela N, Zhang Q, Krystal C, Lum E, Tsai EW, Lipshutz GS, Gritsch HA, Danovitch G, Veale J, Gjertson D, Cecka M, Reed EF. New priorities: Analysis of the New Kidney Allocation System on UCLA patients transplanted from the deceased donor waitlist. Human Immunology. 2017 Jan;78(1):41-48. PMID: 27818166
• Butler CL, Valenzuela NM, Thomas KA, Reed EF. Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. Journal of Immunology Research. 2017;2017:7903471. PMID: 28373996

• Sosa RA, Zarrinpar A, Rossetti M, Lassman CR, Naini BV, Datta N, Rao P, Harre N, Zheng Y, Spreafico R, Hoffmann A, Busuttil RW, Gjertson DW, Zhai Y, Kupiec-Weglinski JW, Reed EF. Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation. Journal of Clinical Investigation Insight. 2016 Dec 8;1(20):e89679. PMID: 27942590
• Valenzuela NM, Hickey MJ, Reed EF. Antibody Subclass Repertoire and Graft Outcome Following Solid Organ Transplantation. Frontiers in Immunology. 2016 Oct 24;7:433. PMID: 27822209
• Zhang Q, Reed EF. The importance of non-HLA antibodies in transplantation. Nature Reviews Nephrology. 2016 Aug;12(8):484-95. PMID: 27345243
• Hickey MJ, Valenzuela NM, Reed EF. Alloantibody Generation and Effector Function Following Sensitization to Human Leukocyte Antigen. Frontiers in Immunology. 2016 Feb 4;7:30. PMID: 26870045
• Zhang X, Reed EF. A novel HLA-C null allele, HLA-C*08:121N. HLA. 2016 Jan;87(1):55-6. PMID: 26814415

• Valenzuela NM, Reed EF. Antibodies to HLA Molecules Mimic Agonistic Stimulation to Trigger Vascular Cell Changes and Induce Allograft Injury. Current Transplantation Reports. 2015 Sep;2(3):222-232. PMID: 28344919
• Reed EF. Technical and conceptual advances in histocompatibility and immunogenetics inform on mechanisms of transplant rejection and pave the way to development of novel therapies. Current Opinion in Organ Transplantation. 2015 Aug;20(4):444-5. PMID: 26126199
• Salehi S, Reed EF. The divergent roles of macrophages in solid organ transplantation. Current Opinion in Organ Transplantation. 2015 Aug;20(4):446-53. PMID: 26154913
• Thomas KA, Valenzuela NM, Gjertson D, Mulder A, Fishbein MC, Parry GC, Panicker S, Reed EF. An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. American Journal of Transplantation. 2015 Aug;15(8):2037-49. PMID: 25904443
• Wozniak LJ, Hickey MJ, Venick RS, Vargas JH, Farmer DG, Busuttil RW, McDiarmid SV, Reed EF. Donor-specific HLA Antibodies Are Associated With Late Allograft Dysfunction After Pediatric Liver Transplantation. Transplantation. 2015 Jul;99(7):1416-22. PMID: 26038872
• Valenzuela NM, Trinh KR, Mulder A, Morrison SL, Reed EF. Monocyte recruitment by HLA IgG-activated endothelium: the relationship between IgG subclass and FcγRIIa polymorphisms. American Journal of Transplantation. 2015 Jun;15(6):1502-18. PMID: 25648976
• Thomas KA, Valenzuela NM, Reed EF. The perfect storm: HLA antibodies, complement, FcγRs, and endothelium in transplant rejection. Trends in Molecular Medicine. 2015 May;21(5):319-29. PMID: 25801125
• Kwon MH, Zhang JQ, Schaenman JM, Cadeiras M, Gjertson DW, Krystal CA, Laks H, Ardehali A, Deng MC, Shemin RJ, Reed EF. Characterization of ventricular assist device-mediated sensitization in the bridge-to-heart-transplantation patient. The Journal of Thoracic and Cardiovascular Surgery. 2015 Apr;149(4):1161-6. PMID: 25702320
• Li F, Wei J, Valenzuela NM, Lai C, Zhang Q, Gjertson D, Fishbein MC, Kobashigawa JA, Deng M, Reed EF. Phosphorylated S6 kinase and S6 ribosomal protein are diagnostic markers of antibody-mediated rejection in heart allografts. The Journal of Heart and Lung Transplantation. 2015 Apr;34(4):580-587. PMID: 25511749